Werewolves were Rooftop Guards from Episode 4: Jailbreak and Episode 5: A Tangled Web in Sly 2: Band of Thieves that were encountered in Prague. They were brown wolves with red eyes and a black and white piece of shredded clothing. As their weapon of choice, the werewolves would use a morning star to repeatedly crush their foes. They sometimes posed as gargoyles around the Contessa's prison and castle and would break free of the stone if the player neared them. Some of them could also release small purple spiders that would pounce to attack, similar to the Contessa. Sly could defeat them with 4 hits, Murray with 2 hits and Bentley with 8 hits.
- Despite being normal wolves, they are called Werewolves due to their savage nature and intimidating appearance.
- When Sly escapes from a werewolf, you can hear them howl.
- Their moveset consists of a downward smash, a swing, and a charged swing, all of which are similar to some of Sly's moves.