Roxana Ortega was born in Los Angeles. She was raised in Fullerton, California by her Peruvian mother and Mexican-American father.
Her first performance was in the fourth grade in a school production of the King and I. After graduating from U.C. Berkeley with a degree in American Cultures and the Arts, she became involved in Bay Area theater and improvisation.
- Roxana Ortega is the first actress to voice Carmelita Fox, who has had a new voice actor for every game.