They were huge, wine red insects with four wings, and small, dark-purple spots in their backs. If they spotted an intruder wandering around their territory, they would attack and try to suck their blood. If they succeeded, they would show their satisfaction with an expression of fullness before spitting out the blood in disgust. They were quite agile due to their ability of flight. Sly's Binocucom says that they all enjoy Sunday picnics.
- The animation that these enemies display after defeating Sly marks the only time in the series that blood is seen, excluding any green "guts" from creatures like rats and bees.
- One of the mosquitoes is used as transportation for Sly Cooper when dueling with Mz. Ruby, and was later destroyed by her voodoo spell.
- It can be assumed that the mosquito guards are all female, as only female mosquitos in real life suck blood.
|Sly Cooper and the Thievius Raccoonus guards|
|Tide of Terror|
|Sunset Snake Eyes|
|Fire in the Sky|
|The Cold Heart of Hate|